| Outline of Heart Simulator | Research Subjects | Simulation of Diseases and Development of New Therapies |
| Development of Therapeutic Devices | Experiments on Cells and Virtual Cells | Experimental Validation | Computational Science | etc. |

Introduction of Research
Computational Science 3/4

As seen in the left microscopic image of myocardium, cells are arranged with a certain regularity. Therefore, we may define a micro-unit consisting of a number of cells, and regard local myocardium as a repetition of such a micro-unit. The mechanical characteristics of myocardium can then be directly expressed by the finite element virtual cells. With this model we can use the homogenization method, a powerful tool to link the intra-cellular microstructure to the dynamics of the heart. However, the homogenization method has not been applied to practical problems because the computational cost increases explosively in nonlinear problems. We are doing further research to overcome this problem.

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