Introduction of Research
Outline of Heart Simulator 5/6
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When a myocyte is electrically stimulated, the intracellular
Ca concentration rises to allow cross-bridge formation between thick and
thin filaments, and the myocyte contracts. This process is called excitation-contraction
coupling, and several physiological models are currently available to describe
the state of a cross-bridge by evolutional equations. By combining such
models with the aforementioned electrophysiology models, we can compute
instantaneous contraction forces. Interestingly, 55%-60% of the blood in
the ventricle is ejected with each beat, even though the shortening of each
myocyte is only 10%-15%. Our simulator can reveal the mechanisms of this
ingenious pumping function of the heart.
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