| Outline of Heart Simulator | Research Subjects | Simulation of Diseases and Development of New Therapies |
| Development of Therapeutic Devices | Experiments on Cells and Virtual Cells | Experimental Validation | Computational Science | etc. |

Introduction of Research
Outline of Heart Simulator 5/6

When a myocyte is electrically stimulated, the intracellular Ca concentration rises to allow cross-bridge formation between thick and thin filaments, and the myocyte contracts. This process is called excitation-contraction coupling, and several physiological models are currently available to describe the state of a cross-bridge by evolutional equations. By combining such models with the aforementioned electrophysiology models, we can compute instantaneous contraction forces. Interestingly, 55%-60% of the blood in the ventricle is ejected with each beat, even though the shortening of each myocyte is only 10%-15%. Our simulator can reveal the mechanisms of this ingenious pumping function of the heart.

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